Istituto Ortopedico Rizzoli
Prof.ssa Maria Paola Landini
The Rizzoli Orthopaedic Institute in Bologna is recognized as an Institute for Research, Hospitalization and Health Care (IRCCS) since 1981. The high level of healthcare is the result of the intense scientific research and the transfer of these results into clinical practice. Rizzoli is a modern hospital, equipped with innovative operating theaters and comfortable patient rooms for a total of 293 beds. Approximately 20,000 patients are hospitalized per year of which over 50% come from other regions.
The Rizzoli Orthopaedic Institute is the main national referral center for chemotherapy and surgery of sarcomas. The Institute participates in international and national protocols for musculoskeletal and soft tissue sarcomas. Based on data from national protocols for the treatment of osteosarcoma and Ewing sarcoma it is estimated that about 50% of Italian patients with osteosarcoma and Ewing’s sarcoma are diagnosed and treated at the Rizzoli.
At Rizzoli research is programmed according to a multi-year plan developed following six main research lines, including Musculo-Skeletal Oncology.
Research in oncology is aimed at the definition of diagnostic and therapeutic parameters to translate into clinical practice, in order to stratify patients at different “risk” categories. Mechanisms of drug resistance and preclinical evaluation of new anticancer drugs or new therapeutic strategies, including those for specific targets to be used in therapy are analyzed. Guidelines are also defined for new therapeutic protocols for sarcomas.
Studies on bone metastases in relation to bone tissue resorption mechanisms and analysis of minimally invasive techniques (CT-guided needle thermal ablation) as adjuvant or palliative therapies are performed.
The research line uses a digitized database of more than 45,000 cases of cancer lesions or pseudo-tumors of the musculoskeletal system, the Tissue Bank with more than 8,000 samples of tumor tissue and three national registries (the Primary malignant bone tumor registry, the Osteosarcoma registry and the Li-Fraumeni syndrome registry).
Finally, in collaboration with the research lines Computer Aided Medicine and Regenerative Musculo-Skeletal Medicine computerized surgery is studied and planned using homoplastic bone grafts and vascularized fibular autografts in Orthopedic Oncology. Subsequent functional assessment of cancer patients and studies on the use of mesenchymal stem cells combined with platelet gel to improve integration of massive bone allografts in skeletal reconstructions in cancer patients are also performed.
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