Rizzoli Orthopaedic Institute
Prof.ssa Maria Paola Landini
The Rizzoli Orthopaedic Institute in Bologna has been recognized as a Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) since 1981. The high healthcare assistance is due to intensive scientific research and transferring of research results into clinical practice.
Rizzoli is a modern hospital equipped with state-of-the-art operating rooms and comfortable hospital rooms with 293 beds. It carries out approximately 20,000 admissions per year, of which more than 50% are related to patients from outside the region.
The Rizzoli Orthopaedic Institute is the leading national reference centre for the chemotherapy and surgical treatment of sarcomas. The Institute participates in international and national protocols for sarcomas of the skeleton and soft tissues. Based on data from the national protocols for osteosarcoma and Ewing’s sarcoma treatment, it is estimated that about 50% of Italian patients with osteosarcoma and Ewing’s sarcoma are diagnosed and treated by Rizzoli.
At Rizzoli, research is programmed according to a multi-year plan that develops along six major research lines, including Musculoskeletal Oncology.
Oncological research aims to define diagnostic and therapeutic parameters to be transferred into clinical practice to create a hierarchy of the categories of patients at risk. Mechanisms of drug resistance are analyzed, and preclinical evaluations of new anticancer drugs or new therapeutic strategies are carried out, including the search for specific targets to be used in therapy. On top of that, guidelines for new treatment protocols in sarcomas are also defined.
Studies are carried out on bone metastases in relation to the mechanisms of bone resorption and the analysis of minimally invasive techniques (needle thermoablation / CT-guided) as adjuvant therapies or palliative care.
The research line uses a digitized database of more than 45,000 cases of tumour or pseudo-tumour lesions of the musculoskeletal apparatus of the Tissue Bank with more than 8,000 samples of tumour tissue and of three national registers (Primitive Malignant Tumors of Bone, Osteosarcoma and Li-Fraumeni Syndrome).
Finally, in collaboration with the Computer-Aided Medicine and Musculoskeletal Regenerative Medicine research lines, the Institute carries out studies on the computerized planning of surgical interventions with homoplastic bone grafts and vascularized fibula autografts in Orthopaedic Oncology. Furthermore, it conducts studies on the subsequent functional evaluation of oncological patients and studies on the use of mesenchymal stem cells associated with platelet gel to improve the integration of massive bone allografts in reconstructive skeletal surgery oncological patients.
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