Mondino National Neurological Institute Foundation – IRCSSADDRESS
Via Mondino, 2 - 27100 PaviaFOUNDED
Neurosciences – Neuro-oncology
Dott. Fabio Blandini
The Casimiro Mondino National Neurological Institute Foundation, in Pavia, Italy, is a Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) and a private body, whose activity is devoted to “central nervous system (CNS) and peripheral nervous system (PNS) disorders”.
Officially recognized as an IRCCS in 1973, the Institute is a reference point, both nationally and internationally, for research into, and diagnosis and treatment of, stroke and cerebrovascular diseases, neurodegenerative diseases (Parkinson’s, Alzheimer’s and motor neuron diseases) and multiple sclerosis, as well as headache and epilepsy, in adults and children/adolescents. The Foundation also specializes in child neuropsychiatry, neuromuscular disorders, brain tumors, neuro-ophthalmology, sleep medicine, neurogenic dysphagia, and rare diseases in adults and children.
Around 20 years ago, the Institute also introduced a structured care and research program in the field of neuro-oncology: www.mondino.it/neuroncologia.
This program is run by a dedicated team, but it involves the Institute in a transversal way, benefiting from the latter’s decades of expertise in the fields of radiology, neurophysiology and neuroimmunology.
The activity is carried out by 4 neurologists from the Neuro-oncology Unit, coordinated by Dr Enrico Marchioni, which has: 12 beds, 4 specialist clinics and a facility for treatment delivered applying MAC (complex macro-activity) and DH (day hospital) models. Most admissions are urgent cases admitted during the diagnostic and therapeutic work-up of primary/secondary nervous system tumors, or of inflammatory, infectious and iatrogenic neurological complications occurring during anti-neoplastic treatments for solid systemic or hematological tumors. Around 30% of patients followed by the Neuro-oncology Unit come from outside the Lombardy region.
The Mondino Foundation collaborates with institutes of excellence and with the local healthcare network: the National Centre of Oncological Hadrontherapy (CNAO), the San Matteo Hospital Foundation, the Maugeri Clinical Institutes, and the local health and social care authority (ASST). The Mondino Foundation also coordinates a diagnostic and care pathway promoted by the provincial oncology department of Pavia.
The primary fields of interest have a strong multidisciplinary character and concern, in addition to primary brain tumors, neurotoxicity and complications related to immunodeficiency.
The research activities have a predominantly clinical and translational slant.
The most important projects concern:
– the latest chemotherapy and radiotherapy treatment regimens for primary brain tumors
– the neurotoxicity of radiotherapy for the treatment of primary brain tumors and neoplasms of the cranial base
– CNS and PNS complications following bone marrow transplants
– the biomolecular diagnosis of primary tumors.
The biological research, to be applied to diagnostic, prognostic and therapeutic ends, focuses mainly on the molecular characterization of diffuse gliomas. The Foundation’s Genomics and Post-Genomics Centre is currently in the process of implementing Next Generation Sequencing techniques for obtaining molecular characterization of brain tumors, to be used for care and translational research purposes. A prospective multi-center study, promoted by the Foundation, is now in progress. It concerns the development, starting from material circulating in the plasma, of techniques for performing “liquid biopsies”, for the diagnosis and follow-up of patients with diffuse glioma.