WG Pathology and Biobanking

Working Group

Preanalytical procedures in Pathology Laboratories do impact enormously on genomic analyses, spanning from feasibility of a specific molecular assay to proper interpretation of results obtained from experiments. Based on these premises there has been an urgent need to involve more actively the Pathology Laboratories of all Institutes of Cancer Research of the AAC network and to render more homogeneous the workflows of sample collection and analysis. Of note, these samples will be the main substrate of all analyses performed in the framework of the different studies of the disease-related WGs.

At present, this WG is composed of representatives of the Pathology Units of 23 Cancer Institutes. The AIMAC (Associazione Italiana Malati di Cancro), the Italian Association of Cancer Patients has expressed an interest in collaborating with us.

The primary objective of the Pathpology and Biobanking WG is represented by the organization of a shared preanalytical workflow to obtain uniform quality of the biological samples, mainly tissue samples, sent for diagnostic purposes to the Pathology Labs. These samples may be also instrumental for Clinical Trials, biomarker validation studies or construction of certified biobanks. Since the quality of DNA and RNA extracted from samples is key to the success of molecular investigations, we have specifically asked to have a Pathologist and a (Molecular) Biologist involved from each Centre.

To achieve the results we have planned to obtain for each Institute the documents realized by the International Organization for Standardization (ISO) for the pre-analytical phase, in particular those related to the DNA/RNA extraction from formalin fixed paraffin embedded samples as well as from frozen samples. Subsequently, we will elaborate the Standard Operating Procedures (SOPs) for the pre-analytical phase to be shared among all laboratories. The impact and the efficacy of the project will be monitored by a “Ring Study”, which will deal with a quality control of DNA/RNA extracted from tissue samples. These activities will constitute the backbone of the experience of the WG that will foster further activities focused on biobanking.

  • Secretary (of the Executive Board): Caterina Marchiò - IRCCS CANDIOLO

Elisabetta Iannelli – AIMAC | Simonetta Piana – AUSL REGGIO EMILIA | Vincenzo Canzonieri – CRO AVIANO | Maria Lucia Caruso – IRCCS DE BELLIS | Annarita Destro, Massimo Roncalli, Salvatore Renne –  ICH ROZZANO | Stefania D’Atri, Francesca Rizzi – IDI ROMA | Pier Paolo Di Fiore, Giuseppe Renne – IEO MILANO | Edoardo Pescarmona – IFO ROMA | Maria Grazia Daidone, Giancarlo Pruneri – INT MILANO | Maria Montesco, Antonio Scapinello – IOV PADOVA | Alberto Righi – IOR BOLOGNA | Valentina Ancarani – IRST MELDOLA | Bianca Pollo – BESTA MILANO | Giulia Berzero, Entico Marchioni  – MONDINO PAVIA | Alfredo Zito, Angelo Paradiso – ONCOLOGICO BARI | Tiziana Franchin – OPBG ROMA | Marina Stroppiano – GASLINI GENOVA | Fabio Ciceri, Claudio Doglioni – HSR MILANO | Roberto Fiocca – IST GENOVA | Peppino Mirabelli – SDN NAPOLI | Paolo Granziano – CSS S.G. ROTONDO | Fabio Ruggero Maria Corsi – FOND. MAUGERI | Caterina Marchiò, Anna Sapino – IRCC CANDIOLO | Gerardo Botti – PASCALE NAPOLI | Guido Rindi – IRCCS GEMELLI ROMA