Complying with the goal of accelerating clinical and translational research in oncology, the WG joins ACC genomics activities aimed at shifting towards precision medicine by adopting next generation sequencing technologies.
The process streamlines envision:
- Analysis set-up, by investigating specific sets of colorectal cancers (namely, liver metastasis and synchronous colorectal cancers). The employed technology is also expected to allow fast diagnosis of inherited predispositions. Besides their inherent methodological goals, these studies might in the meanwhile provide information concerning genetic heterogeneity of neoplastic lesions and their possible impact on patient outcome.
- Set-up of a national tissue repository of colorectal cancer specimens, and related clinical data. This effort is aimed to exploit a relevant Italian effort in the field (TOSCA study*) by providing researchers with samples (3700 stage II and III patients, median follow-up 4 years), from a randomized trial as a revenue for future studies aimed to explore the impact of genetic derangements on disease progression, moving from solid clinical bases.
*TOSCA; Ann. Oncol 2016, ASCO 2017, NEJM 2017
Manuela Gariboldi – INT MILANO | Alfredo Budillon – PASCALE NAPOLI | Giuseppe Toffoli – CRO AVIANO | Chiara Molinari – IRST MELDOLA | Livio Trusolino – IRCC CANDIOLO | Luca Albarello – HSR MILANO | Grazia Serino – IRCCS DE BELLIS | Riccardo Ricci – IRCCS GEMELLI ROMA | Enzo Medico – IRCC CANDIOLO | Anna Biroccio – IRE ROMA | Giandomenico Russo – IDI ROMA | Orazio Palmieri – S.G. ROTONDO | Teresa Rossi – AUSL-RE | Teresa Manzo – IEO MILANO | Valentina Condelli – IRCCS CROB | Francesca Maddalena – IRCCS CROB | Stefania Tommasi – ONCOLOGICO BARI | Alessandro Poggi – IST GENOVA
Antonio Avallone – PASCALE NAPOLI | Angela Buonadonna – CRO AVIANO | Nicola Silvestris – ONCOLOGICO BARI | Alberto Sobrero – IST GENOVA | Giovanni Luca Frassineti – IRST MELDOLA | Filippo Pietrantonio – INT MILANO | Nicola Fazio – IEO MILANO | Fotios Loupakis – IOV PADOVA | Lisa Salvatore – IRCCS GEMELLI ROMA | Dario Ribero – IRCC CANDIOLO | Marcello Maugeri Saccà – IRE ROMA | Claudio Lotesoriere – IRCCS DE BELLIS | Maurizio Elia – IDI ROMA | Tiziana Latiano – S.G. ROTONDO | Angela Damato – AUSL-RE | Luigi Laghi – HUMANITAS MILANO | Italo Sarno – IRCCS CROB | Oronzo Brunetti – ONCOLOGICO BARI | Claudio Belluco – CRO AVIANO | Renato Cannizzaro – CRO AVIANO | Martina Cavestro – OSR MILANO