WG Genomics

Working Group

ACC, an organization which unites some of the most important Italian research institutes involved in landmark translational studies, has set up working groups to focus on single pathologies whose matrix is the Genomics WG, a research platform that crosscuts the other clinical research groups and which was set up to make molecular analysis technologies more easily accessible to researchers in the Network.

The national IT infrastructure, that is coordinated by a team of bioinformatics scientists based at the European Institute of Oncology (IEO) in Milan, is central to the WG – lead by Luca Mazzarella of the IEO. The team oversees the work of the researchers from each ACC associated Institute. In fact, in every Centre there is a bioinformatics scientist and a wet biologist who are responsible for processing, analysing and then transferring the data obtained from clinical trials to the national computational platform. This data is then integrated with information from scientific literature in order to set up databases, which are equipped with a user-friendly interface, that oncologists can use to select the most appropriate treatment according to the molecular profile of the Patient’s tumour.

The future work of the Working Group will be oriented in three main directions: firstly towards optimizing collaboration within the Network as well as interaction with pharmacology research stakeholders as it is clear that if the use of breakthrough technologies for the molecular characterization of individuals is not matched with a wide range of tailored drugs, all efforts will have been in vain; secondly, and ever more importantly, towards integrating the various methods of molecular analysis – point mutations, increase in sensitivity for structural variants, use of gene expression data and advanced technologies, such as RNA Sequencing  and the sequencing of specific aspects of tumour biology; lastly, towards the development of technologies for the analysis of circulating DNA (liquid biopsy) that will allow analysis of large mutation panels as well as, for example, the metabolomic or proteomic analysis of blood. One of the main obstacles to implementing precision medicine, which is the continual request for Patients’ bioptic material, will thus be overcome.

 

  • Secretary (of the Executive Board): Luca Mazzarella - IEO MILANO

Members
Vanesa Gregorc – HSR MILANO | Davide Cittaro – HSR MILANO | Luca Gianni- HSR MILANO | Giovanni Tonon – HSR MILANO | Paolo Dellabona – HSR MILANO | Silvia Bonfiglio HSR MILANO | Gabriele Bucci – HSR MILANO | Giovanna Torri – HSR MILANO | Ettore Zapparoli – HSR MILANO| Dejan Lazarevic – HSR MILANO | Manuela Sovilla – HSR MILANO | Chiara Lazzari – HSR MILANO | Vincenzo Russo – HSR MILANO | Stefania Tommasi – ONCOLOGICO BARI | Simona De Summa – ONCOLOGICO BARI | Daniela Petriella – ONCOLOGICO BARI |Rosanna Lacalamita – ONCOLOGICO BARI | Maurizio Fanciulli – IRE ROMA | Simonetta Buglioni – IRE ROMA | Francesca De Nicola – IRE ROMA | Frauke Goeman – IRE ROMA | Beatrice Casini – IRE ROMA | Matteo Pallocca – IRE ROMA | Francesco Frassoni – GASLINI GENOVA | Alberto Martini – GASLINI GENOVA | Roberta Maestro – CRO AVIANO | Gustavo Baldassarre – CRO AVIANO |Katia Scotlandi – IOR BOLOGNA | Piero Picci – IOR BOLOGNA | Massimo Serra – IOR BOLOGNA | Davidemaria Donati – IOR BOLOGNA | Mariarosa Incoronato- SDN NAPOLI |Marco Salvatore – SDN NAPOLI |Pier Giuseppe Pelicci – IEO MILANO | Gianmaria Frigè – IEO MILANO | Alessandro Guida – IEO MILANO | Luca Mazzarella – IEO MILANO | Arnaud Gerard Michel Ceol – IEO MILANO | Giorgia Mori – IEO MILANO | Laura Fancello – IEO MILANO | Myriam Alcalay – IEO MILANO | Loris Bernard- IEO MILANO | Saverio Minucci – IEO MILANO | Luisa Maria Lanfrancone – IEO MILANO| Elena Carla Belloni – IEO MILANO | Roberta Carbone – IEO MILANO | Igor Pozdnyakov – IEO MILANO |Laura Matricardi- IOV PADOVA | Lorenza Pasqualini – IOV PADOVA | Giuseppe Opocher- IOV PADOVA | Arcangela De Nicolo – IOV PADOVA | Francesca Schiavi – IOV PADOVA | Stefano Indraccolo – IOV PADOVA | Gaetano Finocchiaro – BESTA MILANO | Tiziana Langella – BESTA MILANO | Bianca Pollo – BESTA MILANO | Rosina Paterra – BESTA MILANO | Fabrizio Tagliavini – BESTA MILANO | Angelo Del Monte – IRST MELDOLA | Paola Ulivi – IRST MELDOLA | Andrea Rocca – IRST MELDOLA | Sara Bravaccini – IRST MELDOLA| Sara Ravaioli – IRST MELDOLA | Massimo Guidoboni – IRST MELDOLA | Jenny Bulgarelli – IRST MELDOLA | Massimiliano Mazza – IRST MELDOLA | Luca Frassinetti – IRST MELDOLA | Chiara Molinari – IRST MELDOLA | Toni Ibrahim – IRST MELDOLA | Laura Mercatali – IRST MELDOLA| Daniele Calistri – IRST MELDOLA | Anna Tesei – IRST MELDOLA | Sonia Ronconi – IRST MELDOLA | Gerardo Musuraca – IRST MELDOLA | Martina Ghetti – IRST MELDOLA | Michela Tebaldi – IRST MELDOLA | Elisabetta Caprini – IDI ROMA | Giandomenico Russo – IDI ROMA | Federica DeGalitiis – IDI ROMA | Alessia Ciarrocchi – AUSL REGGIO EMILIA | Federica Torricelli – AUSL REGGIO EMILIA | Benedetta Donati – AUSL REGGIO EMILIA | Massimo Costantini – AUSL REGGIO EMILIA | Giuseppe Pelosi – UNI MILANO | Giorgio Stassi – UNI PALERMO | Anna Sapino – IRCC CANDIOLO | Enzo Medico – IRCC CANDIOLO | Caterina Marchiò – IRCC CANDIOLO | Tiziana Venesio – IRCC CANDIOLO | Ivan Molineris – IRCC CANDIOLO | Giovanni Apolone – INT MILANO | Maria Grazie Daidone – INT MILANO |Giancarlo Pruneri- INT MILANO | Elena Tamborini – INT MILANO | Federica Perrone – INT MILANO | Maria Luisa Sensi – INT MILANO | Matteo Dugo – INT MILANO | Loris De Cecco – INT MILANO | Massimo Carella – CSS S.G. ROTONDO | Tommaso Mazza – CSS S.G. ROTONDO | Paola Parrella – CSS S.G. ROTONDO | Lucia Anna Muscarella – CSS S.G. ROTONDO | Fabrizio Bianchi – CSS S.G. ROTONDO | Paolo Graziano – CSS S.G. ROTONDO | Franco Fais – IST GENOVA | Ulrich Pfeffer – IST GENOVA | Gabriele Zoppoli – IST GENOVA | Simonetta Zupo – IST GENOVA | Giulia Berzero – MONDINO PAVIA | Concetta Quintarelli – OPBG ROMA | Marco Tartaglia – OPBG ROMA | Nicola Normanno – PASCALE NAPOLI | Gerardo Botti – PASCALE NAPOLI | Pietro Zoppoli – CROB RIONERO IN VULTURE | Valentina Condelli – CROB RIONERO IN VULTURE | Giuseppina Improta – CROB RIONERO IN VULTURE | Francesco La Rocca – CROB RIONERO IN VULTURE | Matteo Landriscina – CROB RIONERO IN VULTURE | Pellegrino Musto – CROB RIONERO IN VULTURE | Francesco Colotta – ICH ROZZANO | Carlo Gaetano – FOND. MAUGERI | Maurizio Martini – IRCCS GEMELLI ROMA