Genomics
Countrywide computer network created to target cancer therapies
-
Secretary
Luca Mazzarella
IEO MILANO
-
Wet Coordinator
Simonetta Buglioni
IRCCS IRE
-
Bioinformatic Coordinator
Giovanni Tonon
OSR MILANO
ACC is the Italian point of reference in translational research having the most important Italian research institutes involved in landmarked translational studies. Furthermore, AC has activated working groups for individual diseases whose matrix is represented by the Genomics WG. The latter is a transversal research platform to other clinical groups created to facilitate access to molecular analysis technologies to researchers who belong to the Network.
The national IT infrastructure, coordinated by a team of bioinformatics scientists set at the European Institute of Oncology (IEO) in Milan, is central to the WG – lead by Luca Mazzarella of the IEO. The team oversees the work of the researchers from each ACC associated Institute.
In each Centre, a bioinformatics scientist and a wet biologist are in charge of the processing, analysis and subsequent transfer of data obtained from clinical trials to the national computational platform. The mutational information flowed to the core is integrated with scientific literature to provide databases with a user-friendly interface that the oncologist can use to identify the best possible treatment for the patient based on her/his molecular profile.
The future work of the Working Group will be oriented in three main directions.
Firstly, the WG is oriented towards optimizing collaboration within the Network and association/alliance with pharmacology research stakeholders in drug research as it is clear that if the most breakthrough technological availability of being able to characterize each individual does not correspond to a wide range of tailored drugs, the effort will remain sterile and fruitless.
Secondly, and even more importantly, integrating the various methods of molecular analysis – point mutations, increase in sensitivity for structural variants, use of gene expression data and advanced technologies, such as RNA Sequencing and the sequencing of specific aspects of tumour biology is a focus of the WG.
Finally, the WG focusses on developing technologies for the analyses of circulating DNA (liquid biopsy) that will allow examining large panels of mutations and even metabolomics or proteomics in the blood. In this way, one of the main obstacles to implementing precision medicine, which is given by the continuous demand for patient biopsy material, will be overcome.
Team
- Bioinformatics
- Wet
-
HSR MILANO
Gabriele Bucci
-
CRO AVIANO
Davide Baldazzi
-
IRE ROMA
Martina Betti
-
IEO MILANO
Luca Mazzarella, Alessandro Guida
-
CSS S.G. ROTONDO
Tommaso Mazza
-
IRST MELDOLA
Michela Tebaldi
-
AUSL REGGIO EMILIA
Federica Torricelli
-
IRCC CANDIOLO
Claudio Isella
-
INT MILANO
Luca Agnelli
-
PASCALE NAPOLI
Riziero Esposito Abate
-
IDI ROMA
Gianluca Scaglione
-
IRCCS CROB
Giovanni Calice
-
IRST MELDOLA
Michela Tebaldi
-
IRST MELDOLA
Davide Angeli
-
ICH ROZZANO
Paolo Kunderfranco
-
IRCCS GEMELLI ROMA
Luciano Giacò
-
IRCCS IOV
Antonio Collesei
-
IOR BOLOGNA
Antonella Laginestra
-
IRCCS SAN RAFFAELE MI
Gabriele Bucci
-
IRCCS SAN RAFFAELE MI
Marco Morelli
-
IRCCS SAN RAFFAELE MI
Giovanni Tonon
-
OSP. POL. S. MARTINO GENOVA
Gabriele Zoppoli
-
SDN NAPOLI
Mario Zanfardino
-
OSP. POL. S. MARTINO GENOVA
Ulrich Pfeffer
-
IRCCS AOU BOLOGNA
Tommaso Pippucci
-
IRST MELDOLA
Nicoletta Ranallo
-
IRST MELDOLA
Chiara Liverani
-
IRCCS SDN
Mario Zanfardino
-
IRE ROMA
Martina Betti
-
IRCCS SAN RAFFAELE MI
Dejan Lazarevic
-
IRCCS SAN RAFFAELE MI
Francesca Borgo
-
ONCOLOGICO BARI
Stefania Tommasi
-
IRE ROMA
Simonetta Buglioni
-
IRCCS GEMELLI ROMA
Maurizio Martini
-
CRO AVIANO
Roberta Maestro
-
CRO AVIANO
Gustavo Baldassarre
-
IEO MILANO
Gianmaria Frigè
-
IRCCS GEMELLI ROMA
Angelo Minucci
-
IOV PADOVA
Francesca Schiavi
-
IDI ROMA
Elisabetta Caprini
-
AUSL REGGIO EMILIA
Alessia Ciarrocchi
-
IRCC CANDIOLO
Enzo Medico
-
INT MILANO
Loris De Cecco
-
CSS S.G. ROTONDO
Massimo Carella
-
OSP. POL. S. MARTINO GENOVA
Ulrich Pfeffer
-
OPBG ROMA
Marco Tartaglia
-
PASCALE NAPOLI
Annamaria Rachiglio
-
CROB RIONERO IN VULTURE
Luciana De Luca
-
ICS MAUGERI
Sandra Atlante
-
IRCCS GASLINI
Isabella Ceccherini
-
IRCCS AOU BOLOGNA
Tommaso Pippucci
-
IOR BOLOGNA
Laura Pazzaglia
-
IOR BOLOGNA
Katia Scotlandi