Glioblastoma is the most common of malignant brain tumours – with approximately 1,500 new cases diagnosed every year in Italy. It is more common in men than in women and mainly occurs in people aged between 55 and 75 years.
The Glioblastoma Working Group set up in Alleanza Contro il Cancro – coordinated by Stefano Indraccolo from the Veneto Oncology Institute (IOV) in Padua, in collaboration with the preclinical coordinator Lucia Ricci-Vitiani from the Italian National Institute of Health and the clinical coordinator Gaetano Finocchiaro from the Besta Neurological Institute in Milan – brings together ten neuro-oncology laboratories in the same number of high standard institutes for comprehensive cancer patient care and research (IRCCS). Their tasks involve exchanging samples and sharing both the results from specific tests and cancer-derived cell lines.
The ACC research on Glioblastoma is mainly focused on three project platforms. The first one concerns the genetic characterization of patient-derived cell lines of Patients from the associated IRCCS Institutes, a very important resource for the in vitro testing of targeted drugs.
The second project aim to enhance knowledge about the small sub-population of long-term survivors – just 5%. The objective is to understand whether there are precise genetic characteristics or characteristics of the tumour microenvironment that are associated with long-term survival.
The purpose of the third project is purely clinical: thanks to a joint effort, a panel (the so-called oncochip) of fifty genes with a high mutation rate has been developed. Sequencing of the samples, using NGS technologies, will allow us to provide clinicians with a genetic profiling service for Glioblastoma, when requested.
- Secretary (of the Executive Board): Stefano Indraccolo - IOV PADOVA
- Head of Pre-Clinical Operations: Lucia Ricci-Vitiani - ISS ROMA
- Head of Clinical Operations: Gaetano Finocchiaro - BESTA MILANO
Lucia Ricci Vitiani, Ugo Testa – ISS ROMA | Marco Paggi – IRE ROMA | Paolo Malatesta – IST GENOVA | Galli Rossella – HSR MILANO | Giuliana Pelicci – IEO MILANO | Tiziana Langella – BESTA MILANO | Daniele Calistri – IRST MELDOLA | Roberta Bertorelle – IOV PADOVA | Concetta Quintarelli – OSP PED B.GESU’ ROMA
Stefano Indraccolo, Giuseppe Lombardi – IOV PADOVA | Gaetano Finocchiaro, Antonio Silvani – BESTA MILANO | Carmine Carapella – IRE ROMA | Salvina Barra – IST GENOVA | Michele Reni – HSR MILANO | Elisabetta Munzone – IEO MILANO | Matteo Simonelli – ICH ROZZANO | Carla Boccaccio – IRCCS CANDIOLO | Toni Hibraim – IRST MELDOLA | Angela Mastronuzzi- OSP PED B.GESU’ ROMA