Breast
On seeking for predictive alterations in response to biologic drugs
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Secretary
Lucia Dal Mastro
IRCCS OSP. POLICLINICO SAN MARTINO (GE)
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Clinical Coordinator
Valentina Guarneri
IOV PADOVA
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Pre Clinical Coordinator
Arcangela Denicolo
IOV PADOVA
The ACC Breast Cancer Working Group primarily concentrates its efforts on obtaining predictive factors from alterations in the cancer cells to develop specific molecular therapies to establish specific preventive treatment for each patient.
The study, which involves 16 of the 23 ACC Institutes – coordinated by the WG secretary, Lucia Del Mastro, who is based at the San Martino Hospital in Genoa – focuses on a cancer subtype for which it is currently more difficult to achieve a high rate of recovery. In particular, the focus of the researchers is on the triple-negative breast cancer that tests negative to the three receptors used in the treatment of other forms of breast cancer (oestrogen, progesterone and Her2 receptors) and for which no specific treatment exists.
The route indicated by Del Mastro involves the use of an oncochip (genetic code created in the laboratory and able to identify essential anomalies in the cancer cells) to identify a panel of genes whose alterations could be responsible for drug resistance but, at the same time, predictive of response to new targeted biological treatments which have much higher efficacy and far lower toxicity.
Besides the expertise of the researchers and the clinicians that make up the Working Group, the strength of the Breast Cancer WG, as for all the other ACC Working Groups, lies in its numbers: 10,000 cases are treated every year in the 16 Institutes involved – very high when compared to the overall number of cases treated nationally. Working through a network means working faster and increasing the probability of success in researching new therapeutic solutions.
Team
- Pre-Clinics
- Clinicians
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CRO AVIANO
Barbara Belletti
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ONCOLOGICO BARI
Stefania Tommasi
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HSR MILANO
Rosa Bernardi
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IOV PADOVA
Arcangela De Nicolo
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IRST MELDOLA
Sara Bravaccini
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CSS S.G. ROTONDO
Paola Parrella
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INT MILANO
Maria Grazia Daidone
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IRCC CANDIOLO
Caterina Marchiò
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IRCCS GEMELLI ROMA
Claudio Sette, Luca Tamagnone
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IRCCS IRE
Giovanni Blandino
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AULS-IRCCS
Moira Ragazzi
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IEO MILANO
Pier Paolo Di Fiore
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IRCCS-CROB
Raffaele Ardito
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ICS MAUGERI
Carlo Morasso
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OSP. POL. S. MARTINO GENOVA
Lucia Del Mastro
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SAN MATTEO
Marco Lucioni
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OSP. POL. S. MARTINO GENOVA
Barbara Cardinali
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IRE ROMA
Patrizia Vici
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PASCALE NAPOLI
Michelino De Laurentiis
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INT MILANO
Serena Di Cosimo
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CRO AVIANO
Fabio Puglisi
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ONCOLOGICO BARI
Francesco Giotta
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OSR MILANO
Gianpaolo Bianchini
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IRCCS CROB
Michele Aieta
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IRST MELDOLA
Ugo De Giorgi
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IRCCS GEMELLI ROMA
Alessandra Fabi
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CSS S.G. ROTONDO
Maria Morritti
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HUMANITAS
Rita De Sanctis
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IEO MILANO
Giovanni Corso
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IOV PADOVA
Valentina Guarneri
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FPO CANDIOLO
Filippo Montemurro
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OSP. POL. S. MARTINO GENOVA
Giulia Buzzatti
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ICS MAUGERI
Fabio Corsi
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SAN MATTEO
Elisa Ferraris
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IRCCS S. CUORE DON CALABRIA
Stefania Gori