The ACC Oncohematology Working Group has 2 main goals for the next 3 years, and will be focused mainly on Aggressive B-cell Lymphomas and Acute Myeloid Leukemias. The WG is coordinated by Enrico Derenzini (IEO), and is composed of 18 sites.
The first goal is the implementation of a “hi-tech” molecular platform for diagnostics, which would be suitable to promote multicenter precision medicine investigator-initiated clinical trials.
The second goal is the functional multi-omics (genomic, proteomic and metabolomic) characterization of TP53 mutated lymphomas and leukemias. Genomic alterations of the TP53 gene have a profound impact on the biology of these diseases, determining chemoresistance and extensive metabolic rewiring. The aim of this study is to define therapeutic vulnerabilities in TP53 dysfunctional Lymphomas and Leukemias, by performing a functional characterization “beyond genomics”, in order to develop precision therapy strategies based on “synthetic lethalities”.
The innovative structure of the WG will allow the gradual integration of additional specific projects from all participating sites.
- Coordinatore Clinico: Fabio Ciceri - OSR MILANO
- Coordinatore Pre Clinico: Giorgia Simonetti - IRST MELDOLA
Maurizio Fanciulli – IRE ROMA | Benedetta Donati – AUSL IRCCS | Sabino Ciavarella – ONCOLOGICO BARI | Valter Gattei – CRO AVIANO | Stefania Crisci – PASCALE NAPOLI | Stefan Hohaus – IRCCS GEMELLI ROMA | Vincenzo Giambra – CSS S.G. ROTONDO | Luca Vago – HSR MILANO | Marina Lanciotti – IRCCS GASLINI | Stefano Pileri – IEO MILANO | Giorgia Simonetti – IRST MELDOLA | Eric Piovan – IOV PADOVA | Carmelo Carlo Stella – ICH ROZZANO | Fiorella D’Auria, Antonella Caivano – IRCCS CROB | Alberto Pisacane – FPO CANDIOLO | Valter Gattei – CRO AVIANO | Cristiana Carniti – INT MILANO | Concetta Quintarelli – OPBG ROMA | Gilberto Fronza – IST GENOVA
Francesco Marchesi – IRE ROMA | Armando Santoro – ICH ROZZANO | Stefano Luminari – AUSL IRCCS | Attilio Guarini – ONCOLOGICO BARI | Michele Spina – CRO AVIANO | Antonello Pinto – PASCALE NAPOLI | Luciana Teofili, Patrizia Chiusolo – IRCCS GEMELLI ROMA | Giovanni Rossi – CSS S.G. ROTONDO | Enrico Derenzini, Corrado Tarella – IEO MILANO | Carlo Dufour – IRCCS GASLINI | Gerardo Musuraca – IRST MELDOLA | Dario Marino – IOV PADOVA | Giuseppe Pietrantuono – IRCCS CROB | Fabrizio Carnevale – FPO CANDIOLO | Michele Spina – CRO AVIANO | Fabio Ciceri – OSR MILANO | Paolo Corradini – INT MILANO | Mattia Algeri – OPBG ROMA | Roberto Lemoli – IST GENOVA